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No Priors

No Priors is an AI interview podcast and media brand founded and hosted by investors Sarah GuoSarah GuoSarah Guo is a venture capitalist, founder and managing partner of Conviction, an early-stage investment firm focused on artificial intelligence, and previously a partner at Greylock.Open the full entry and Elad GilElad GilElad Gil is an entrepreneur, investor and author of High Growth Handbook. He co-founded Mixer Labs and Color, worked at Google and Twitter, runs the multistage investment firm Gil & Co, and co-hosts the No Priors podcast with Sarah Guo.Open the full entry, with episodes beginning in February 2023. It covers research, startups, infrastructure and business applications through guest interviews, host discussions and retrospectives distributed on audio platforms and YouTubeYouTubeYouTube is Google’s video-sharing and creator platform, founded in 2005 by Steve Chen, Chad Hurley, and Jawed Karim and acquired by Google in 2006. Built around video uploading, viewing, and creator earnings, the platform has developed Shorts, YouTube Music, Premium, YouTube TV, and products for children, and is headquartered in San Bruno, California, United States.Open the full entry.

Contents7 sections
Key facts

Founding and the First Interview

In her launch announcement, Sarah Guo described No Priors as an AI podcast created with Elad Gil. A two-minute trailer published on February 2, 2023 introduced conversations with engineers, researchers and entrepreneurs about AI progress and its effects on business, culture and society.⁠[1][2]

Retrospectives, Cross-Channel Collaboration and Industry Interviews

On January 11, the podcast published highlights from 2023, featuring Ilya SutskeverIlya SutskeverIlya Sutskever is a computer scientist who studied under Geoffrey Hinton, helped develop AlexNet and sequence-to-sequence learning, and is a co-founder and former chief scientist of OpenAI. As a board member in 2023 he took part in removing Sam Altman, and after leaving OpenAI in 2024 he founded Safe Superintelligence, which he has led as CEO since 2025.Open the full entry, Mustafa SuleymanMustafa SuleymanMustafa Suleyman is a British AI entrepreneur and CEO of Microsoft AI who co-founded DeepMind and Inflection AI.Open the full entry, Reid HoffmanReid HoffmanReid Hoffman is an American entrepreneur, venture investor, author and podcast host, co-founder of LinkedIn, Inflection AI and Manas AI, and a partner at Greylock. A former PayPal executive, he has built and backed businesses in professional networking, artificial intelligence and drug discovery. His co-authored books include The Startup of You and Blitzscaling.Open the full entry, Daphne KollerDaphne KollerDaphne Koller is an Israeli-born computer scientist and entrepreneur who taught for many years at Stanford University and is known for her work on probabilistic graphical models and her 2004 MacArthur Fellowship. She co-founded Coursera with Andrew Ng in 2012 and in 2018 founded insitro, a machine-learning-driven drug discovery company she leads as CEO.Open the full entry, Noam Shazeer, Arthur Mensch and Jensen Huang. Such compilations reorganized conversations into a retrospective listening format.⁠[4]

A Garry Tan interview released on May 23 used a cross-channel format: its first part appeared on No Priors and its second on Tan's YouTube channel. It covered his transition from entrepreneur to investor, founder selection at Y Combinator and AI startup trends.⁠[5]

From Model Capabilities to Industry Applications

Host Discussions and Computing Infrastructure

In an August 6 episode, Guo and Gil discussed founder ambition, market size and revenue, company-sale timing, computing bottlenecks and regulation. It continued the podcast's format of host conversations alongside guest interviews. Predictions about technology and markets were the hosts' views.⁠[9]

On September 3, Arm CEO Rene Haas joined them to discuss the chip supply chain, CPUs, data-center construction bottlenecks, robotics and manufacturing. The approximately 37-minute episode continued coverage of AI computing infrastructure.⁠[10]

Greg Brockman interview

DotsDots (OpenAI agents)Dots is OpenAI’s always-on AI agent product, introduced in September 2026. Agents use cloud computers and authorized apps to continue tasks, combining user context, proactive research and action review with collaboration through ChatGPT and other interfaces.Open the full entry featured in the discussion of persistent, proactive agents. Brockman described using calendar and work context to help people follow through on commitments made in meetings, while arguing that people should retain authority over goals, values and the boundaries of AI control.⁠[11]

Hosts and Distribution

The program describes Sarah Guo as Conviction's founder and a former Greylock investor, and Elad Gil as a technology entrepreneur and investor. Apple Podcasts lists Conviction as the creator and a weekly release frequency. Those platform labels are not corporate registration or ownership records.⁠[12]

The official link page provides audio, YouTube and TikTok destinations and links to both hosts' social accounts. YouTube carries full video interviews and chapters, while Apple Podcasts provides audio, episode descriptions and dates.⁠[13][5][12]

Sources

  1. No Priors launch announcement (opens in a new window)
  2. This is No Priors (opens in a new window)
  3. The bot Cicero can collaborate, scheme, and build (opens in a new window)
  4. A No Priors Clip Show: The Best of 2023 (opens in a new window)
  5. No Priors Ep 66 | With Y Combinator President and CEO Garry Tan (opens in a new window)
  6. NVIDIA’s Jensen Huang on AI Chip Design, Scaling Data Centers (opens in a new window)
  7. The Best of 2024 with Sarah Guo and Elad Gil (opens in a new window)
  8. The Best of 2025 (So Far) with Sarah Guo and Elad Gil (opens in a new window)
  9. Chasing Trillion-Dollar Companies, Founder Ambition, Token Budgets, and Regulatory Capture with Sarah & Elad (opens in a new window)
  10. Redefining Chip Architecture with Arm CEO Rene Haas (opens in a new window)
  11. The Changing Physics of Cybersecurity and Drug Development with OpenAI President Greg Brockman (opens in a new window)
  12. No Priors: Artificial Intelligence | Technology | Startups (opens in a new window)
  13. No Priors | AI, Technology and Science (opens in a new window)