No Priors
No Priors is an AI interview podcast and media brand founded and hosted by investors Sarah GuoSarah GuoSarah Guo is a venture capitalist, founder and managing partner of Conviction, an early-stage investment firm focused on artificial intelligence, and previously a partner at Greylock.Open the full entry and Elad GilElad GilElad Gil is an entrepreneur, investor and author of High Growth Handbook. He co-founded Mixer Labs and Color, worked at Google and Twitter, runs the multistage investment firm Gil & Co, and co-hosts the No Priors podcast with Sarah Guo.Open the full entry, with episodes beginning in February 2023. It covers research, startups, infrastructure and business applications through guest interviews, host discussions and retrospectives distributed on audio platforms and YouTubeYouTubeYouTube is Google’s video-sharing and creator platform, founded in 2005 by Steve Chen, Chad Hurley, and Jawed Karim and acquired by Google in 2006. Built around video uploading, viewing, and creator earnings, the platform has developed Shorts, YouTube Music, Premium, YouTube TV, and products for children, and is headquartered in San Bruno, California, United States.Open the full entry.
Contents7 sections
Key facts
2023Founding and the First Interview
In her launch announcement, Sarah Guo described No Priors as an AI podcast created with Elad Gil. A two-minute trailer published on February 2, 2023 introduced conversations with engineers, researchers and entrepreneurs about AI progress and its effects on business, culture and society.[1][2]
The first full episode, released the same day, featured Noam BrownNoam BrownNoam Brown is a research scientist at OpenAI who works on reasoning, reinforcement learning, self-play, and multi-agent AI. The poker programs Libratus and Pluribus, which he developed with his advisor Tuomas Sandholm, defeated top professional players; at Meta he helped develop CICERO, an AI for the game Diplomacy; and at OpenAI he was a foundational contributor to reasoning models such as o1.Open the full entry, then at MetaMetaMeta (Meta Platforms, Inc.) is a publicly listed American technology company, renamed from Facebook in 2021, that operates social communication, digital advertising, virtual reality, smart glasses and artificial intelligence businesses.Open the full entry, discussing Cicero and the game Diplomacy. The approximately 59-minute conversation covered cooperation, negotiation, strategic reasoning and the relationship between game research and more general AI.[3]
2024Retrospectives, Cross-Channel Collaboration and Industry Interviews
On January 11, the podcast published highlights from 2023, featuring Ilya SutskeverIlya SutskeverIlya Sutskever is a computer scientist who studied under Geoffrey Hinton, helped develop AlexNet and sequence-to-sequence learning, and is a co-founder and former chief scientist of OpenAI. As a board member in 2023 he took part in removing Sam Altman, and after leaving OpenAI in 2024 he founded Safe Superintelligence, which he has led as CEO since 2025.Open the full entry, Mustafa SuleymanMustafa SuleymanMustafa Suleyman is a British AI entrepreneur and CEO of Microsoft AI who co-founded DeepMind and Inflection AI.Open the full entry, Reid HoffmanReid HoffmanReid Hoffman is an American entrepreneur, venture investor, author and podcast host, co-founder of LinkedIn, Inflection AI and Manas AI, and a partner at Greylock. A former PayPal executive, he has built and backed businesses in professional networking, artificial intelligence and drug discovery. His co-authored books include The Startup of You and Blitzscaling.Open the full entry, Daphne KollerDaphne KollerDaphne Koller is an Israeli-born computer scientist and entrepreneur who taught for many years at Stanford University and is known for her work on probabilistic graphical models and her 2004 MacArthur Fellowship. She co-founded Coursera with Andrew Ng in 2012 and in 2018 founded insitro, a machine-learning-driven drug discovery company she leads as CEO.Open the full entry, Noam Shazeer, Arthur Mensch and Jensen Huang. Such compilations reorganized conversations into a retrospective listening format.[4]
A Garry Tan interview released on May 23 used a cross-channel format: its first part appeared on No Priors and its second on Tan's YouTube channel. It covered his transition from entrepreneur to investor, founder selection at Y Combinator and AI startup trends.[5]
On November 7, Jensen Huang returned to discuss chip design, interconnects, data-center expansion and robotics. The December 26 retrospective included Huang, Andrej KarpathyAndrej KarpathyAndrej Karpathy is an AI researcher and educator, one of the founding members of OpenAI, who served as Tesla’s Director of AI and led the Autopilot computer vision team from 2017 to 2022, founded the AI education company Eureka Labs in 2024, and joined Anthropic in 2026 to work on pre-training research; at Stanford he designed and taught the university’s first deep learning course, CS231n, and he coined the term “vibe coding.”Open the full entry, Bret Taylor, Sora team members, Dmitri DolgovDmitri DolgovDmitri Dolgov is an autonomous-driving engineer and executive who co-founded Google’s self-driving car project in 2009, served as Waymo’s CTO, and since 2021 has been co-CEO of Waymo with Tekedra Mawakana.Open the full entry, Dylan Field and Alexandr WangAlexandr WangAlexandr Wang is an artificial intelligence entrepreneur, a co-founder and former chief executive officer of Scale AI. He joined Meta in June 2025 as the company’s first chief AI officer and leads Meta Superintelligence Labs. His work spans AI training data, model evaluation, government applications, and personal agents.Open the full entry, covering computing, agents, video generation, autonomous driving and data.[6][7]
2025From Model Capabilities to Industry Applications
A highlights episode released on October 31 revisited interviews with Harvey's Winston Weinberg, World LabsWorld LabsWorld Labs is a spatial intelligence company headquartered in San Francisco, founded in 2024 by Fei-Fei Li and others. It develops “world models” that generate, reconstruct and simulate interactive 3D worlds from text, images and video, as well as technology for robot learning and simulation; its first product is the 3D world generation tool Marble. In September 2026 AMD announced an agreement to acquire World Labs; the transaction has not yet closed.Open the full entry' Fei-Fei Li, MercorMercorMercor is a San Francisco-based artificial intelligence company that began as an AI hiring platform and shifted to recruiting domain experts such as doctors and lawyers for major AI labs to supply data for model training and evaluation, with its valuation rising rapidly over several funding rounds.Open the full entry's Brendan Foody and Abridge's Shiv Rao. Topics included legal services, spatial intelligence, labor markets and healthcare, reflecting the podcast's continued attention to industry applications.[8]
The compilation also included Dan Hendrycks on the geopolitics of superintelligence, Noubar Afeyan on entrepreneurship and OpenAIOpenAIOpenAI is an artificial intelligence research and product organization founded in 2015 that develops the GPT model series, ChatGPT, Codex and a developer API, and conducts research on image, speech, video and intelligent agents. After its 2025 restructuring, the nonprofit OpenAI Foundation continues to control the for-profit OpenAI Group PBC. Its growth has involved large-scale fundraising and compute partnerships, and has also been accompanied by controversies over governance, copyright, privacy and AI safety.Open the full entry researchers on reasoning models and Deep Research, retaining research, scientific entrepreneurship and safety alongside business interviews.[8]
2026Host Discussions and Computing Infrastructure
In an August 6 episode, Guo and Gil discussed founder ambition, market size and revenue, company-sale timing, computing bottlenecks and regulation. It continued the podcast's format of host conversations alongside guest interviews. Predictions about technology and markets were the hosts' views.[9]
On September 3, Arm CEO Rene Haas joined them to discuss the chip supply chain, CPUs, data-center construction bottlenecks, robotics and manufacturing. The approximately 37-minute episode continued coverage of AI computing infrastructure.[10]
October 15, 2026Greg Brockman interview
The program released an approximately 39-minute interview with Greg BrockmanGreg BrockmanGreg Brockman is a software engineer and entrepreneur, co-founder and president of OpenAI, and a former chief technology officer of Stripe. His work spans payment infrastructure, engineering organizations and large AI systems, alongside public discussion of AI development and governance.Open the full entry, hosted by Sarah Guo and Elad Gil, covering GPT-6GPT-6GPT-6 is an OpenAI model family introduced in 2026, spanning Astra, Sol, Luna and subsequent 6.1 versions. Its applications include conversation, coding, computer use and professional work, with capabilities and availability varying across models and products.Open the full entry, mathematics and drug discovery, Dots, OpenAI DaybreakDaybreak (OpenAI cybersecurity program)Daybreak is OpenAI’s trusted-access cybersecurity program for verified practitioners and organizations. It provides models, support and partnerships for authorized security work through access levels including Blue and Red, alongside support for defenders of essential services.Open the full entry and human control of AI. Statements about research progress and future security spending were the guest’s views, not independent experimental validation.[11]
DotsDots (OpenAI agents)Dots is OpenAI’s always-on AI agent product, introduced in September 2026. Agents use cloud computers and authorized apps to continue tasks, combining user context, proactive research and action review with collaboration through ChatGPT and other interfaces.Open the full entry featured in the discussion of persistent, proactive agents. Brockman described using calendar and work context to help people follow through on commitments made in meetings, while arguing that people should retain authority over goals, values and the boundaries of AI control.[11]
Hosts and Distribution
The program describes Sarah Guo as Conviction's founder and a former Greylock investor, and Elad Gil as a technology entrepreneur and investor. Apple Podcasts lists Conviction as the creator and a weekly release frequency. Those platform labels are not corporate registration or ownership records.[12]
Sources
- No Priors launch announcement (opens in a new window)
- This is No Priors (opens in a new window)
- The bot Cicero can collaborate, scheme, and build (opens in a new window)
- A No Priors Clip Show: The Best of 2023 (opens in a new window)
- No Priors Ep 66 | With Y Combinator President and CEO Garry Tan (opens in a new window)
- NVIDIA’s Jensen Huang on AI Chip Design, Scaling Data Centers (opens in a new window)
- The Best of 2024 with Sarah Guo and Elad Gil (opens in a new window)
- The Best of 2025 (So Far) with Sarah Guo and Elad Gil (opens in a new window)
- Chasing Trillion-Dollar Companies, Founder Ambition, Token Budgets, and Regulatory Capture with Sarah & Elad (opens in a new window)
- Redefining Chip Architecture with Arm CEO Rene Haas (opens in a new window)
- The Changing Physics of Cybersecurity and Drug Development with OpenAI President Greg Brockman (opens in a new window)
- No Priors: Artificial Intelligence | Technology | Startups (opens in a new window)
- No Priors | AI, Technology and Science (opens in a new window)